MiR-92 Family Members Form a Cluster Required for Notochord Tubulogenesis in Urochordate Ciona savignyi
نویسندگان
چکیده
منابع مشابه
Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis.
Cell elongation is a fundamental process that allows cells and tissues to adopt new shapes and functions. During notochord tubulogenesis in the ascidian Ciona intestinalis, a dramatic elongation of individual cells takes place that lengthens the notochord and, consequently, the entire embryo. We find a novel dynamic actin- and non-muscle myosin II-containing constriction midway along the antero...
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Ascidians are among the most distant chordate relatives of the vertebrates. However, ascidians share many features with vertebrates including a notochord and hollow dorsal nerve cord. A screen for N-ethyl-N-nitrosourea (ENU)-induced mutations affecting early development in the ascidian Ciona savignyi resulted in the isolation of a number of mutants including the complementing notochord mutants ...
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Eye movements in vertebrates are controlled by six extraocular muscles innervated by three of the cranial nerves – the oculomotor, trochlear and abducens. Incorrect development of this wiring network can lead to eye movement disorders, such as the congenital condition Duane retraction syndrome (DRS), which results in squint (strabismus). In DRS patients, the abducens nerve is often absent, and ...
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We have successfully designed a custom genome browser for visualization of the genome of the invertebrate chordate Ciona intestinalis. We describe the use of the genome browser to visualize the conservation between Ciona intestinalis and a related species, Ciona savignyi. Visualizing genomic conservation between these two organisms is important for determining genes and regulatory regions that ...
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The miR-17∼92 cluster family is composed of three members encoding microRNAs that share seed sequences. To assess their role in cerebellar and medulloblastoma (MB) development, we deleted the miR-17∼92 cluster family in Nestin-positive neural progenitors and in mice heterozygous for the Sonic Hedgehog (SHH) receptor Patched 1 (Ptch1(+/-)). We show that mice in which we conditionally deleted the...
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ژورنال
عنوان ژورنال: Genes
سال: 2021
ISSN: 2073-4425
DOI: 10.3390/genes12030406